THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS AND DOCKING STUDIES OF SOME STRUCTURALLY DIVERSE FLAVONOIDS AND DESIGN OF NEW ALDOSE REDUCTASE INHIBITORS

Aldose reductase (AR) plays an important role in the development of several long-term diabetic complications.Inhibition of AR activities is a strategy for controlling complications arising from chronic diabetes.Several AR inhibitors have been reported in the literature.Flavonoid type compounds are shown to have significant AR inhibition.The objecti

The ever increasing urban population growth has created many implications in land use planning in the most of developing countries.Traditional methods of spatial planning are still useful, but they need to be upgraded according to new methodological, technological possibilities and full complexity of spatial planning.The factors which influence the

Abstract Historical papers are often locally damaged by exogenous influences and/or have endogenously degraded paper areas.The stabilization of such papers is very important because further use of the object can cause additional damage.Different types of nanocellulose are interesting as a novel stabilizing materials for paper due to their close str

The temporal phytoplankton biomass variation at two Neotropical reservoirs during an extreme drought season were analyzed.Here we sought to evaluate the main abiotic factors involved in dynamics of phytoplankton during this drought period.The main difference between the reservoirs was the intensive fish and shrimp farming in one of the Sheetmetal D